Biology and chemistry

Arc Institute Evo / Evo 2

DNA language models with context up to a million nucleotides: they assess the impact of mutations, annotate genomes and generate sequences. Evo 2 is trained on genomes from all domains of life.

Developer
Arc Institute (with Together AI, Stanford, NVIDIA), USA
First release
Feb 2024
Latest release
Feb 2026
Sizes
1B – 40B
License
Commercial use allowedApache 2.0
Running
On your own serverNeeds a GPU
Industries
Healthcare, Science and research
Deploy on your server Hugging Face GitHub

What it does

  • Assessing the likely harmfulness of genetic variants for research
  • Annotating genomes of microorganisms and plants
  • Finding promising sequences in breeding and synthetic biology

Where it is used

Biotech and pharmaAgricultural genetics and breedingResearch labs

Hardware requirements

LaptopLaptop or regular PC, up to 8 GB of VRAM — smaller versions
no versions
1 GPUOne GPU with 16–80 GB — mid-size versions
fits
ClusterServer with several GPUs — flagship versions
fits

Versions

  1. Evo 2 20B
  2. Evo 2 7B 262k
  3. Evo 2 1B, 7B, 40B
  4. Evo 1 (7B)

How to run it

On your own serverWeights are downloaded from Hugging Face and served with vLLM (load and API) or llama.cpp (modest hardware). The model then runs in a closed network with no per-request fees.Hugging Face
How much hardware you needCalculate the VRAM for the model size, context length and number of concurrent requests.Open the hardware calculator

I can set this up end to end: pick the model size, deploy it on your server and connect it to your systems.

Frequently asked questions

Can Arc Institute Evo / Evo 2 be used in a commercial project?

Yes. License: Apache 2.0. It allows commercial use, but it is still worth having a lawyer review the license before launch.

What hardware does Arc Institute Evo / Evo 2 need?

At minimum: One GPU with 16–80 GB — mid-size versions. Without a GPU the model is not practical. You can calculate the exact VRAM for your model size and context in the hardware calculator.

Does Arc Institute Evo / Evo 2 support Russian?

Language does not matter for this model: it does not work with text.

Where can I download Arc Institute Evo / Evo 2 and what does it cost?

The Arc Institute Evo / Evo 2 weights are open and free to download. You only pay for the hardware it runs on and for the setup. Source links are at the bottom of this page.

How I deploy it for clients

  1. SelectionI pick the model size for your task and hardware and test it on your examples.
  2. DeploymentI deploy it on your server or in a closed network and provide an API.
  3. Fine-tuningI fine-tune it on your data (LoRA) or connect a knowledge base — whichever is cheaper for the task.
  4. IntegrationI connect it to your CRM, ERP, bot, website or team chat and set up monitoring.

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Details

Source: huggingface.co/api/models?author=arcinstitute. Data checked against the model card on 22 Sep 2026. Have a lawyer review the license before commercial launch.